A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R3 PAu(SR′), R = Ph, Cy, Et; SR′H = 6-Mercaptopurine and R = Et; SR′H = 6-Thioguanine

نویسندگان

  • David Crump
  • George Siasios
  • Edward R. T. Tiekink
چکیده

The antitumour activities of four triorganophosphinegold(I) thiolates, R(2)PAu(S'R) [R = Ph, Cy, Et; SR'H = 6-mercaptopurine and R Et; SR'H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy(3)PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy(3) PAu(6-MP)] and [Et(3)PAu(6-TG)].

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عنوان ژورنال:
  • Metal-Based Drugs

دوره 6  شماره 

صفحات  -

تاریخ انتشار 1999